Kidney Osmolarity Medical Experiment Discussion
The experiment on regulation of osmolarity by kidney was conducted with 15 participants that were divided into 3 groups. 5 member of each group drunk either water, Gatorade or water with 7g of NaCl. The analysis of the urine was performed according to the protocol. It was expected that urinal filtration rates, specific gravity and excretion of NaCl will be different after the intake of three different substances with different osmolarity, namely water, Gatorade and NaCl. As it was supposed, the highest was the excretion of NaCl after intake of 80 ml of water with 7 g of salt. The specific gravity and was also the highest in this group during all 2-hours period while the volume of urine was the lowest. This may be is explained by the physiological mechanism of regulating osmolarity. After the intake of water with 7g of salt the osmolarity of plasm increased and ADH was released to reach the ADH
receptors that are present in kidneys in the collective ducts. This increased water reabsorbtion to dissolve the plasma and to preserve the level of plasma osmolarity on the level of 300 mlOsm/l. Because of the increased reabsorbtion plasma osmolatiry dropped. This resulted in the decline of the ADH level.
Results of Arden that drunk Gatorade were unusual with significantly higher volume of urine 9,3-10,67ml/min during the first 1,5 hours while the average was between 3,298ml/min and 4, 346 ml/min. This may be explained by additional water intake before the experiment. This research is important for demonstration of the mechanisms of osmolarity regulation. It is also valuable for making a decision what solution to take to replenish the deficit. Obviously, for the routine maintaing of water balance water is the best while people intake salt and
other electrolytes with food. To replenish deficit in the case of severe trainings when food is not available Gatorade is better as it provides NaCl that people lose with sweat during muscular work. Finally, a conclusion
that exceptional salt intake is proved because consumption of more then daily norm of salt will result if preservation of water in the organism to that is regulated by hormones. Increased volume of water in the vessels
will lead to rise of blood pressure, increased preload to the heart and other issues.
Works Cited
John E. Hall. Guyton and Hall Textbook of Medical Physiology, 12th edition. Saunders, 2010. Stuart Ira Fox. Human Physiology. McGraw-Hill, …
